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OBJECTIVE To investigate the effect of antiepileptic drugs, especially carbamazepine and valproate, on intelligence in prenatally exposed children of mothers with epilepsy. METHODS Intelligence of 182 children of mothers with epilepsy (study group) and 141 control children was tested in a blinded setting at preschool or school age using Wechsler Preschool(More)
Although maternal ingestion of antiepileptic drugs is strongly suspected of causing congenital defects, particularly oral clefts, the effect of epilepsy itself or a combined effect of drug intake and epilepsy have not been excluded as etiological factors. Very little is known about fetal oxygenation during a maternal grand mal epileptic seizure. We describe(More)
154 pregnancies of 140 epileptic patients were observed in a prospective study. The number of seizures during pregnancy and 3 first puerperal months was compared with the number of seizures during the 12 months preceding pregnancy. An increase in the number of seizures was noticed in 32% of the cases, a decrease in 14% and unchanged frequency in 23% of the(More)
111 pregnancies of epileptic women on phenytoin therapy were observed in a prospective study. Maternal serum phenytoin concentrations were measured monthly or bi-weekly during pregnancy, labor and puerperium. The concentration decreased towards the end of pregnancy and was lowest at delivery. In 48% of the patients the drug dosage had to be increased to(More)
Clobazam was added to the previous antiepileptic drug therapy of 90 children suffering from drug resistant epilepsy. Ten patients became seizure free, although four of these later developed tolerance. Thirty-three patients experienced a decrease in seizure frequency, and 24 of these, too, developed tolerance. Forty-four patients showed no change in seizure(More)
Eleven epileptic patients, candidates for surgical treatment, were examined in order to localize epileptic foci. The daily doses of antiepileptic drugs (AEDs) were reduced by fifty per cent or less, and the reduced dosages were maintained until a seizure had occurred. The reduction resulted in seizures within five days among all patients, and the number of(More)
Head circumference after the first year of life was investigated in 144 children of epileptic mothers ('study group'). Fifty-two children had been exposed to phenytoin monotherapy, 19 to carbamazepine monotherapy, 27 to drug combinations including barbiturates, 29 to other drug combinations, and 17 children had not been exposed to antiepileptic drugs (AEDs)(More)