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PLK (polo-like kinase) belongs to a family of serine/threonine kinases and represents the human counterpart of polo in Drosophila melanogaster and of CDC5 in Saccharomyces cerevisiae. It is strongly involved in spindle formation and chromosome segregation during mitosis. We have shown previously that PLK mRNA expression correlates with the mitotic activity(More)
Recent studies have shown that elevated levels of urokinase plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1) in breast cancer correlate with an increased risk of a reduced relapse-free survival time and shortened overall survival times. Urokinase PA and PAI-1 are independent prognostic indicators for breast cancer. The fact that(More)
Urokinase plasminogen activator (uPA) is a proteolytic enzyme implicated in cancer invasion and tumor progression. Urokinase PA and its inhibitor (PAI-1) appear to be new and independent prognostic markers in breast cancer. To investigate how uPA- and PAI-1-levels correlate with angiogenesis and tumor vessel invasion, we counted microvessels and their tumor(More)
Recent studies have shown that urokinase (uPA) is an independent prognostic marker in breast cancer. uPA plays a key role in the degradation of tumor matrix and promotes tumor progression. Macrophage expression of uPA appears to be important in this context. Our objective in the present study was to provide evidence that tumor growth factor-beta (TGF-beta)(More)
58 carcinomas of the urinary bladder as well as 11 carcinomata in situ and 10 biopsies of normal mucosa were investigated for their proliferative activity by means of nuclear area morphometry, silver staining of nucleolar organizing regions (NOR) and immunohistochemical staining of the proliferating cell nuclear antigen (PCNA) and the Ki67 antigen. In(More)
The RNase protection assay was performed for RNA expression (Gastrin, CCK-B and CCK-C receptor); a radiobinding assay was used to detect the CCK-B receptor on crude membranes of tumor tissue. In none of investigated carcinomas the high affinity gastrin/CCK-B receptor was detected, whereas low affinity binding was observed in 30%, indicating the expression(More)
In this study we examined the P170-expression (mdr-phenotype) in 42 non-Hodgkin's Lymphomas with variant entities immunohistochemically with the mab JSB1. The mdr-phenotype was related to the tumor proliferation as measured by Ki67-expression and AgNOR numbers. Furthermore the mdr-phenotype was related to the tumor associated T-lymphocytes. The(More)
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