A. Girard

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One-bead one-compound (OBOC) combinatorial peptide libraries have been used to identify ligands and modulators for a wide variety of biological targets. While being very efficient with linear peptides, OBOC libraries with N-terminally blocked peptides or with unsequenceable building blocks require encoding. To fully exploit OBOC combinatorial methods with(More)
Simulation models for large systems have earned the reputation of eating up hours of computer time. This problem can be attributed in part to the fact that a significant amount of bookkeeping time is required to keep future events in their proper sequence. Many methods have been proposed to improve the efficiency of this operation but few results have been(More)
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