A. G. Kozlovsky

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In the course of our previous work we isolated alkaloids such as agroclavine-I and epoxy-agroclavine-I from Penicillium citrinum VKM FW-800 as a microorganism isolated from permafrost1,2). This fungus was shown to co-produce two other alkaloid compounds, which were extractable only under acidic conditions. Positive staining by Dragendorff's reagent but(More)
To investigate the regulation of the biosynthesis of ergot alkaloids by end products, the effect of exogenous agroclavine-1 and epoxyagroclavine-1 on their accumulation byP. sizovae was studied. The added alkaloids stimulated considerably their own biosynthesis depending on their concentration and time of introduction. The stimulating effect of both(More)
Data were obtained on the species composition of mycelial fungi isolated from the air of workrooms and production premises in cheese-making and meat-processing plants. The strains studied were shown to be capable of producing various low molecular weight compounds. Many of them are mycotoxins such as α-cyclopiazonic acid (CPA), mycophenolic acid (MPA),(More)
The uptake of exogeneous 14C-roquefortine by Penicillium farinosum cells and its metabolism was followed. Growth and roquefortine biosynthesis of three Penicillium species during a cultivation period of 14 d were investigated. Furthermore, the effect of cultivation conditions viz. various culture media on roquefortine uptake and biosynthesis as well as(More)
Medium composition, cultivation temperature, and pO2 had a regulatory effect on production of ergot alkaloids (EA) and quinocitrinines (QC) by the fungal strain Penicillium citrinum VKM F-4043 D. Maximal accumulation of EA and QC occurred at 24 and 28°C, respectively. Maximal EA synthesis occurred at 40% pO2, while at 10–20% the conditions were optimal for(More)
Over 30 strains of various Penicillium sp. isolated from food have been screened for the ability to synthesize mycotoxins of an alkaloid nature. The most productive were P. expansum, P. raciborskii, P. puberulum, P. commune, P. viridicatum, P. chrysogenum, P. palitans, P. purpurescens and P. cyclopium. The separate components of the alkaloid mixtures have(More)
A new culturePenicillium farinosum synthesizing roquefortine and 3, 12-dihydroroquefortine was found. UnlikeP. roqueforti, a known producer of these compounds, the culture under study does not synthesize clavine alkaloids. The maximal roquefortine content was observed in the late logarithmic and early stationary growth phases while the maximal 3,(More)
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