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The in vivo experiments established that isobutyl methyl xanthine inhibits phosphodiesterase activity and activates adenylate cyclase in the skeletal muscles and myocardium. The preparation prevents phosphodiesterase activity from increasing due to physical exercises. Against a background of the latter it activates adenylate cyclase and prevents the cAMP… (More)
Protein kinase strong-associated with acetyl-CoA-carboxylase is isolated from the liver of chicken and 300-fold purified with alimentary intensification of lipogenesis and under the effect of nicotinic acid against this background. The obtained enzymes are studied comparatively. It is found that their preparations are phosphorylated with different rate,… (More)
A Golgi-rich fraction has been isolated from the chicken glandular stomach mucosa cells and characterized. Interaction of the [3H]retinol--cellular retinol-binding protein complex with Golgi-rich fraction is shown. The uptake process is specific and saturable. Free retinol does not penetrate to a Golgi-rich fraction. An assumption is advanced that… (More)
The paper deals with the system of enzymic breakdown of exogenic NAD+, NADH, NADP+, NADPH in the guinea pig taenia coli. The break down of NAD, NADH is more intensive than that of NADP+ and NADPH. The enzymic breakdown occurs due to the functioning of pyrophosphatase and glycohydrolase, the latter being considerably more active.
Sites of cAMP and ATP binding which regulate acetyl-CoA-carboxylase phosphorylation rate characterized under conditions of lipogenesis intensification and nicotinic acid action on this enzyme 1500 fold purified and containing proteinkinase activity. The acetyl-CoA-carboxylase preparation contains only one type of the cAMP binding sites which possess higher… (More)
Changes of acetyl-CoA-carboxylase (EC 184.108.40.206) activity and the NAD content in the liver tissue were studied in dynamics after excessive administration of nicotinic acid to chickens. It is established that in chickens, which were given a high-carbohydrate diet after fasting, administration of nicotinic acid at first causes a fall of the acetyl-CoA-activity… (More)
A protein which specifically binds [3H]retinol in vitro and has a sedimentation coefficient of 2S was isolated from the soluble fraction of chicken glandular stomach intermediate zone mucosa cells and purified to homogeneity. The purification procedure included gel filtration through Sephadex G-75 and G-50 and ion-exchange chromatography on DEAE-cellulose.… (More)