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This paper is a critique of Norman Daniels' and James Sabin's 'Accountability for Reasonableness' framework for making priority-setting decisions in health care in the face of widespread disagreement about values. Accountability for Reasonableness has been rapidly gaining worldwide acceptance, arguably to the point of becoming the dominant paradigm in the(More)
We have analysed the distribution of the ΔF508 mutation and the haplotypes of cystic fibrosis (CF) bearing chromosomes among the Israeli CF population. The population was classified according to its ethnic origin and included 3 groups, Ashkenazi Jews, Sephardic/Oriental Jews and Arabs. Haplotype B (KM19 allele 2, XV2c allele 1) was found to be the(More)
The accuracy of first-order Euler and higher-order time-integration algorithms for grid-based Langevin equations collision models in a specific relaxation test problem is assessed. We show that statistical noise errors can overshadow time-step errors and argue that statistical noise errors can be conflated with time-step effects. Using a higher-order(More)
We present initial results for the self-consistent beamcloud dynamics simulations for a sample LHC beam, using a newly developed set of modeling capability based on a merge [1] of the three-dimensional parallel Particle-In-Cell (PIC) accelerator code WARP [2] and the electron-cloud code POSINST [3]. Although the storage ring model we use as a test bed to(More)
The Heavy Ion Fusion Virtual National Laboratory is developing the intense ion beams needed to drive matter to the High Energy Density regimes required for Inertial Fusion Energy and other applications. An interim goal is a facility for Warm Dense Matter studies, wherein a target is heated volumetrically without being shocked, so that welldefined states of(More)
Lawrence Livermore National Laboratory, Lawrence Berkeley National Laboratory, Princeton Plasma Physics Laboratory, Mission Research Corporation, Science Applications International Corporation, Sandia National Laboratories Abstract One approach for heating a target to "Warm Dense Matter" conditions (similar, for example, to the interiors of giant planets or(More)
The circadian clock exists in virtually every cell and regulates key biological processes in cells and tissues. Even in cancer cells, DNA synthesis, cell division and tumor growth are gated by the circadian clock. This study examined the gene expression profiles of transplanted mouse breast tumor cells under normal light-dark (LD) as well as constant dark(More)
Accelerators for heavy-ion inertial fusion energy (HIF) have an economic incentive to fit beam tubes tightly to beams, putting them at risk from electron clouds produced by emission of electrons and gas from walls. Theory and PIC simulations suggest that the electrons will be radially trapped in the ≥1 kV ion-beam potential. We are beginning studies on the(More)
We consider beams which are described by a 4D transverse distribution f(x, y, x′, y′), where x′ ≡ px/pz and z is the axial coordinate. A two-slit scanner is commonly employed to measure, over a sequence of shots, a 2D projection of such a beam’s phase space, e.g., f(x, x′). Another scanner might yield f(y, y′) or, using crossed slits, f(x, y). A small set(More)
We present simulations and analysis of the heating of warm dense matter (WDM) foils by ion beams with energy less than 1MeV per nucleon to target temperatures of order 1 eV. Simulations were carried out using the multi-physics radiation hydrodynamics code HYDRA and comparisons are made to an analytical model and the code DPC. We simulate possible targets to(More)