A F Zappala
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Data are presented for the hydrolytic degradation of idoxuridine (5-iodo-2′-deoxyuridine) in aqueous solution over a wide range of hydrogen ion concentration (pH 1.3 to 12.0). The over-all reaction… Continue Reading
In acid solution, idoxuridine (5-iodo-2′-deoxyuridine) is decomposed by light to form 2′-deoxyuridine and material whose U.V. absorption has been destroyed. Idoxuridine is hydrolyzed by heat to form… Continue Reading
Data are presented to show that the principal decomposition products of idoxuridine ophthalmic solution in acidic media (pH 1.3 to 6.7) are 5-iodouracil and 2-deoxyribose. A trace of 2′-deoxyuridine… Continue Reading
The described method involves separation of panthenol or pantothenate from its decomposition products and subsequent alkaline hydrolysis. The hydrolysis products are chlorinated and iodine is… Continue Reading