A F Tordoff

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1 A single electroconvulsive shock (ECS) of 150 V for 1 s increased the concentration of rat brain 5-hydroxyindoleacetic acid (5-HIAA) but did not alter brain 5-hydroxytryptamine (5-HT) or tryptophan concentrations 3 h later. 2 A single ECS decreased 5-HT synthesis 3 h and 6 h later. Synthesis was back to normal after 24 hours. The ECS-treated rats did not(More)
1 The content and distribution of 5-hydroxytryptamine (5-HT) between subcellular fractions from rat whole brain (excluding cerebellum) were examined following repeated lithium administration. 2 Lithium chloride (3 mEq/kg body wt. s.c.) administered twice daily for 3 days produced no change in the 5-HT content of primary subcellular fractions (P1-nuclear;(More)
Pretreatment of rats with aminooxyacetic acid (AOAA; 40 mg/kg) raised the concentration of rat brain GABA and inhibited the hyperactivity produced by increasing brain 5-hydroxytryptamine (5-HT) concentration by administration of tranylcypromine and L-tryptophan. The maximum effect was seen 90 min after AOAA injection with smaller effects 30 and 180 min(More)
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