Gravitational unloading causes atrophy of muscle fibers and can lead to destruction of cytoskeletal and contractile proteins. Along with the atrophic changes, unloaded muscle frequently demonstrates significant shifts in the ratio of muscle fibers expressing fast and slow myosin heavy chain isoforms. Stretching of the m. soleus during hindlimb suspension… (More)
Here, the possibility of proteomic and metabolomic analysis of the composition of exhaled breath condensate of neonates with respiratory support. The developed method allows non-invasive collecting sufficient amount of the material for identification of disease-specific biomarkers. Samples were collected by using a condensing device that was incorporated… (More)
The approach of hydrogen/deuterium exchange combined with ultrahigh resolution mass spectrometry was applied for investigation of conformational changes of supermetallized ubiquitin ions with cerium(III) atoms. The dependencies of the hydrogen/deuterium exchange efficiency on the charge state of ubiquitin ion, the number of associated cerium atoms, as well… (More)
Nitric oxide is a universal molecule which regulates numerous functions in the body. In the retina, nitric oxide plays a regulatory role modulating synaptic transmission between photoreceptors and bipolar cells; it also has a toxic role and is a necessary inducer of the development of apoptosis in the outer nuclear layer and the ganglion cell layer. We… (More)
Proteomic analysis of the urine was used for noninvasive diagnostics of abnormalities in newborns treated in the neonatal intensive care unit. This approach can be used to differentiate between infectious and noninfectious respiratory disorders.
This study was designed to collect and perform a proteomic analysis of expired air condensate in newborns receiving respiratory support at the Department of Resuscitation and Intensive Care. The proteomic composition of expired air condensate was evaluated in newborns at various stages of development and with different abnormalities.