A. E. Baisa

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We evaluated the efficacy of derivatives of creatine and amino acids (CrAA) for decreasing cerebral injury in rats with transient middle cerebral artery occlusion (MCAO). Neuroprotective effects of amides of creatine and glycine (CrGlyOEt), phenylalanine (CrPheNH2), thyrosine (CrTyrNH2), and GABA (CrGABAOEt) were investigated. Brain injury was evaluated on(More)
The reproducibility of brain injury was evaluated by simulating ischemia in rats by 30-min occlusion of the middle cerebral artery. The selected ischemia-reperfusion protocol was characterized by high reproduction of the striatal neuron injury, which fact suggests this model for studies of nerve tissue reactions to injury and for evaluation of the(More)
The neuroprotective activity of creatine amides – amino acid derivatives of creatine – was studied in a model of cerebral ischemia created by transient occlusion of the middle cerebral artery (OMCA) in rats. The neuroprotective effect of treatment with glycine (creatinylglycine ethyl ester acetate), phenylalanine (creatinyl-L-phenylalaninamide acetate),(More)
The aim of the present work was to test the hypothesis that early ischemic preconditioning provides effective protection of the brain against ischemic damage via effects on cerebral blood flow. Experiments were performed using male Wistar rats anesthetized with thiopental using two methods to produce ischemia: 1) ligation of the left common carotid and left(More)
We hypothesize that early ischemic preconditioning (IPC) can afford protection against focal brief and prolonged cerebral ischemia with subsequent reperfusion as well as permanent brain ischemia in rats by amelioration of regional cerebral blood flow. Adult male Wistar rats (n=97) were subjected to transient (30 and 60 minutes) and permanent middle cerebral(More)
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