A. De Stefano

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Lung cancer is one of the most common causes of cancer-related death worldwide in men and women, and, despite the recent remarkable scientific advances, drug treatment is still unsatisfactory. Polycomb protein chromobox homolog 7 (CBX7) is involved in several biological processes, including development and cancer progression, indeed the lack of CBX7 protein(More)
This work describes a model able to synthetize the surface EMG (electromyography) signal acquired from tibialis anterior and gastrocnemious medialis muscles during walking of asymptomatic adult subjects. The model assumes a muscle structure where the volume conductor is represented by multiple layers of anisotropic media. This model originates from analysis(More)
Purpose: Although the anti–EGF receptor (EGFR) monoclonal antibody cetuximab is an effective strategy in colorectal cancer therapy, its clinical use is limited by intrinsic or acquired resistance. Alterations in the "sphingolipid rheostat"—the balance between the proapoptotic molecule ceramide and the mitogenic factor sphingosine-1-phosphate (S1P)—due to(More)
Running Title: SphK1 and cetuximab resistance in colorectal cancer Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. In this study we investigated the contribution of sphingosine kinase 1 (SphK1) overexpression to cetuximab resistance, both intrinsic or acquired, in colorectal cancer. In preclinical models(More)
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