A.D. Ormerod

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More than 50 interventions have been used to treat hidradenitis suppurativa (HS), and so therapy decisions can be challenging. Our objective was to summarize and appraise randomized controlled trial (RCT) evidence for HS interventions in adults. Searches were conducted in Medline, Embase, CENTRAL, LILACS, five trials registers and abstracts from eight(More)
Cytotoxic T lymphocyte antigen-4 (CTLA-4), a membrane bound inhibitory receptor whose expression is induced on activated T cells, has been established as an important regulator of T cell responses and serves to maintain peripheral tolerance. Additionally, recent characterization of a novel mechanism of extrinsic suppression mediated by the soluble isoform(More)
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