A. D. McKinnon

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Nitrogen-containing bisphosphonate drugs inhibit bone resorption by inhibiting FPP synthase and thereby preventing the synthesis of isoprenoid lipids required for protein prenylation in bone-resorbing osteoclasts. NE10790 is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak anti-resorptive agent. Although NE10790 was a(More)
Coral reefs are in decline worldwide due to a combination of local and global causes. Over 40% of the recent coral loss on Australia's Great Barrier Reef (GBR) has been attributed to outbreaks of the coral-eating Crown-of-Thorns Seastar (CoTS). Testing of the hypotheses explaining these outbreaks is hampered by an inability to investigate the(More)
The biological oceanography of waters adjacent to Australia's North West Cape (21° 49′ S, 114° 14′ E) was studied during the austral summers of 1997/98 and 1998/99. We measured egg production rate (EPR) by the small paracalanid copepods that dominated the calanoid community. Bottle incubation experiments were conducted at a shallow (∼20 m) station in the(More)
Current immunotherapy of posterior uveitis is non-specific and limited by drug toxicity and unpredictable relapses on therapy. Alternative modes of therapy being investigated using the rat model of experimental autoimmune uveoretinitis (EAU) have included the induction of tolerance with oral administration of milligram quantities of retinal antigens. In(More)
The coastal zone of the Great Barrier Reef shelf, with an area of 30,000 km(2) and a water volume of 300 km(3), receives an average annual input of sediment on the order of 14-28 Mty(-1)--an estimated two- to fourfold increase since European settlement. There is considerable concern about the impact and ultimate fate of terrestrially-derived nutrients(More)
The influence of polymer architecture on cellular uptake and transport across Caco-2 cells of novel amphiphilic polyelectrolyte-insulin nanocomplexes was investigated. Polyallylamine (PAA) (15 kDa) was grafted with palmitoyl chains (Pa) and subsequently modified with quaternary ammonium moieties (QPa). These two amphiphilic polyelectrolytes (APs) were(More)
Egg production rates by the dominant copepod species in five rivers inNortheastern Australia were measured. An undescribed Oithona speciesproduced 2.3–15.3 eggs female−1 d−1,Oithona aruensis 0.8–11.3 eggs female−1 d−1, Parvocalanus crassirostris 1.3–36.2 eggsfemale−1 d−1, and Bestiolina similis3.6–51.4 eggs female−1 d−1. Oithona spp.appear to feed(More)
PURPOSE To describe a new model of posterior capsule opacification (PCO) in rodents METHODS An extracapsular lens extraction (ECLE), by continuous curvilinear capsulorrhexis and hydrodissection, was performed in 42 consecutive Brown Norway rats. Animals were killed at 0, 6, and 24 hours and 3, 7, and 14 days after surgery. Eyes were enucleated and(More)
Lewis rats were immunised with retinal S-antigen to induce experimental autoimmune uveitis and experimental autoimmune pinealitis. The blood-retinal and blood-pineal 'barrier sites' were examined by transmission electron microscopy. Inflammatory cell movement through Bruch's membrane involved separation of its constituent layers, cell migration through(More)
The pro-apoptotic protein Bax plays a key role in the mitochondrial signalling pathway. Upon induction of apoptosis, Bax undergoes a conformational change and translocates to mitochondrial membranes, where it inserts and mediates the release of cytochrome c from the intermembrane space into the cytosol. However, the domains of Bax that are essential for the(More)