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BACKGROUND Psychiatric side effects are common during interferon-alfa (IFN-alfa) therapy and often responsible for early treatment discontinuation, thus limiting its therapeutic potential. Depression is considered the hallmark of these side effects. However, irritability, anger/hostility, and manic/hypomanic episodes have also been reported, suggesting that(More)
Prevention tools are challenged by risky behaviors that follow their adoption. Speed increase following helmet use adoption was analyzed among bicyclists enrolled in a controlled intervention trial. Speed and helmet use were assessed by video (2621 recordings, 587 participants). Speeds were similar among helmeted and nonhelmeted female cyclists (16.5 km/h(More)
In 2009-2010, the H1N1 episode occurred in a general context of decreasing public confidence in vaccination. We assumed opposition to vaccination in general to be an 'unfounded fear', reflecting ignorance and perceived vulnerability among low-socioeconomic status (SES) people, and opposition to the H1N1 vaccine a 'legitimate concern' reflecting the elite's(More)
The aim of this study was to investigate psychosocial factors associated with perceived disease severity, with emphasis on informational processing, in 185 consecutive patients with chronic hepatitis C. Medical data, information sources regarding chronic hepatitis C, and attentional coping styles were assessed. The patients considered their hepatitis C a(More)
AIM To examine the psychological impact of chronic hepatitis C (CHC) diagnosis in a large cohort of CHC patients as compared with other stressful life events and chronic diseases carrying a risk of life-threatening complications. METHODS One hundred and eighty-five outpatients with compensated CHC were asked to self-grade, using a 100-mm visual analogue(More)
A very significant decline in the number of road casualties has been observed recently in France, concomitantly with a dramatic increase in law enforcement. The aim of this study was (i) to assess changes in attitudes about road traffic accident (RTA) prevention initiatives in France from 2001 to 2004 and (ii) to identify factors associated with an increase(More)
OBJECTIVES We investigated behavioral changes in a large cohort of drivers to identify underlying causes of the decline in road casualties in France. METHODS In 2001 and 2004, 11,240 participants used self-administered questionnaires to report attitudes toward road safety and driving behaviors. Injury road traffic collisions were recorded from 2001 to(More)
INTRODUCTION Half of fatal injuries among bicyclists are head injuries. While helmet use is likely to provide protection, their use often remains rare. We assessed the influence of strategies for promotion of helmet use with direct observation of behaviour by a semi-automatic video system. METHODS We performed a single-centre randomised controlled study,(More)
AIMS To compare ways of coping with breast cancer in acute and chronic periods and to approach their efficiency on psychological adaptation at each time. METHODS Psychometric evaluation of 151 breast cancer women the day before surgery (T1), and of 107 of them 6 months later (T2), with self-rated questionnaires (CHIP Scale, HADS), "t Student" tests,(More)