A. Caballero

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A model of mutation-selection-drift balance incorporating pleiotropic and dominance effects of new mutations on quantitative traits and fitness is investigated and used to predict the amount and nature of genetic variation maintained in segregating populations. The model is based on recent information on the joint distribution of mutant effects on bristle(More)
The phenomenon that the genetic variance of fitness components increase following a bottleneck or inbreeding is supported by a growing number of experiments and is explained theoretically by either dominance or epistasis. In this article, diffusion approximations under the infinite sites model are used to quantify the effect of dominance, using data on(More)
Inconsistencies between equations for the effective population size of populations with separate sexes obtained by two different approaches are explained. One approach, which is the most common in the literature, is based on the assumption that the sex of the progeny cannot be identified. The second approach incorporates identification of the sexes of both(More)
T. Mukai and co-workers in the late 1960s and O. Ohnishi in the 1970s carried out a series of experiments to obtain direct estimates of the average coefficient of dominance (h) of minor viability mutations in Drosophila melanogaster. The results of these experiments, although inconsistent, have been interpreted as indicating slight recessivity of(More)
Diffusion methods were used to investigate the fixation probability, average time until fixation and extinction, and cumulative heterozygosity and genetic variance for single mutant genes in finite populations with partial inbreeding. The critical parameters in the approximation are the coefficient of inbreeding due to nonrandom mating (F) and the effective(More)
T HE dominance of genes controlling fitness components and other quantitative characters is important for theoretical predictions concerning the maintenance of genetic variability (see e.&, CABALLERO and KEIGHTLEY 1994). Consider, for instance, mutation selection balance at a diallelic autosomal locus with mutation rate p to the deleterious allele and(More)
Populations with small census sizes are at risk because of the loss of genetic variability and the increase of inbreeding and its harmful consequences. For situations with different numbers of males and females, several hierarchical designs have been proposed to control inbreeding through the fixation of individuals' contributions. An alternative method,(More)
We investigate the sources of bias that affect the most commonly used methods of estimation of the average degree of dominance (h) of deleterious mutations, focusing on estimates from segregating populations. The main emphasis is on the effect of the finite size of the populations, but other sources of bias are also considered. Using diffusion(More)
In master-slave teleoperation systems the control loop is closed through the human operator. He 1 acts as a controller generating actuating signals based in visuat and kinesthetic cues. It is then indispensable to have a model of his behavior in order to design and study this type of systems coherently. Up to now only simplified arm dynamic models have been(More)