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We report a new technique called Digital microfluidic Immunocytochemistry in Single Cells (DISC). DISC automates protocols for cell culture, stimulation and immunocytochemistry, enabling the interrogation of protein phosphorylation on pulsing with stimulus for as little as 3 s. DISC was used to probe the phosphorylation states of platelet-derived growth(More)
BACKGROUND Whereas disease surveillance for infectious diseases such as rubella is important, it is critical to identify pregnant women at risk of passing rubella to their offspring, which can be fatal and can result in congenital rubella syndrome (CRS). The traditional centralized model for diagnosing rubella is cost-prohibitive in resource-limited(More)
Microfluidics or lab-on-a-chip (LOC) 4 diagnostic devices have the potential to provide fast, laboratory-quality results to expedite clinical decisions at various point-of-care (POC) settings, including outpatient clinics, emergency rooms, and intensive care units (1). Unfortunately , these technologies remain out of reach in the developing world, where(More)
Multiple wireless technologies are converging to run on personal handhelds. The plethora of communication standards next to the cost issues of deeper submicron processing require handheld platforms to shift from sets of multiple application specific ICs (ASICs) to multi-purpose Multi-Processor System-on-Chip (MPSoC) on which Software Defined Radios (SDR)(More)
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