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Particulate interactions are dominated by aspects such as surface topography, exposed chemical moieties, environmental conditions, and thermodynamic properties such as surface free energy (γ). The absolute value and relative magnitude of surface energies of a drug and excipients within a formulation can significantly influence manufacture, processing, and(More)
Historical thermal plume studies from four Maryland power plants (Calvert Cliffs, Chalk Point, Dickerson, and Wagner) were used to test the realism of the CORnell MIXing Zone Expert System (cormix). Test data were from a wide range of challenging discharge environments, including a large freshwater river (Potomac), a narrow tidal estuary (Patuxent), a wide(More)
The effect of differing densities of poly (ethylene glycol-2000) (PEG2000) at the particle surface of polystyrene-poly (ethylene glycol-2000) (PS-PEG2000) particles was assessed in terms of hydrophobic interaction chromatography (HIC) and the in vitro and in vivo behaviour of the particles. The particles, with different surface densities of PEG, were(More)
  • A. Brindley
  • The Journal of allergy and clinical immunology
  • 1999
The phase out of chlorofluorocarbon (CFC) propellants has necessitated the reformulation of pressurized metered dose inhalers (pMDIs) with hydrofluoroalkane (HFA) propellants. One of the main challenges has been that conventional surfactants used for CFC-based pMDIs were not soluble in HFAs. Since one of the main aims of a pMDI is to deliver a reproducible(More)
To date limited consideration has been given to the physical interaction between inhaled drug particles and pulmonary surfactant (PS). This study combines atomic force microscopy (AFM) with a Langmuir-Blodgett (LB) approach to quantify the force of adhesion between micronised budesonide particles and simulated PS monolayers. A LB approach was used to(More)
Four 96-h in situ bioassays were conducted on or near the striped bass spawning grounds in the Delaware River within the States of Delaware, New Jersey and Pennsylvania, USA during 1989 to determine if water quality was sufficient to support larval survival. Tests were accomplished by holding 500 striped bass yolk-sac larvae in each of two 75 L chambers at(More)
Bovine serum albumin (BSA) was chosen as a model protein. Three solutions of different concentrations of 5, 20 and 50 mg/ml were prepared, characterised and subjected to electrohydrodynamic atomization (EHDA). The 5 and 20 mg/ml solutions were atomized successfully and mode selection (M-S) maps were drawn for both concentrations to find out regions of(More)
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