A Breitholtz Emanuelsson

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The distribution patterns of ochratoxin A and its nontoxic dechloro-analogue ochratoxin B were studied in rats using whole-body autoradiography. No prominent difference in distribution patterns was found that could explain why the rat is the animal most susceptible to ochratoxin A-induced renal cancer or why ochratoxin B is less toxic than ochratoxin A.
A derivative of ochratoxin A was linked to bovine serum albumin in such a way that the carboxylic group of the toxin was left free. Injection of the conjugate into rabbits resulted in sensitive antibodies towards ochratoxin A, which were used in an enzyme-linked immunosorbent assay.
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