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Bioinformatics tools enable researchers to move rapidly from genome sequence to vaccine design. EpiMer and EpiMatrix are computer-driven pattern-matching algorithms that identify T cell epitopes. Conservatrix, BlastiMer, and Patent-Blast permit the analysis of protein sequences for highly conserved regions, for homology with other known proteins, and for(More)
UNLABELLED The genomic variability of HIV viruses circulating in different regions of the world has impeded the development of a globally relevant HIV vaccine. Broadly conserved HIV-1 cytotoxic T cell (CTL) epitopes were identified by screening protein sequences in the Los Alamos National Laboratory (LANL) HIV sequence database with a sequence parsing and(More)
Defined T cell epitopes for West Nile (WN) virus may be useful for developing subunit vaccines against WN virus infection and diagnostic reagents to detect WN virus-specific immune response. We applied a bioinformatics (EpiMatrix) approach to search the WN virus NY99 genome for HLA B*07 restricted cytotoxic T cell (CTL) epitopes. Ninety-five of 3,433 WN(More)
ZDivision of Anatomy, Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Biilowsvej 13, DK-1870 Frederiksberg C, Denmark 2Division of Animal Genetics, Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, BiJlowsvej 13, DK-1870 Frederiksberg C. Denmark 3Department of Cell(More)
AIMS The study aimed to compare the addition of felodipine to metoprolol, and of the replacement of metoprolol by felodipine, with continuation of metoprolol, in patients with angina pectoris despite optimal beta-blockade. METHODS AND RESULTS The study was double-blind, parallel, randomized and controlled, and comprised 363 patients from 27 outpatient(More)
A method for the generation of circuit models for fast thermal-electrical simulation of 3D device structures with a circuit simulator is proposed. It has been used for simulation of the influence of layout parameters on the Safe Operating Area of a BJT and to study the mechanisms that start breakdown processes. For a thermally instable switch-on behaviour(More)
The processionary caterpillar, Thaumetopoea processionea, caused much inconvenience in the Netherlands in 1996-1997; from the medical point of view, mostly itching and skin rash. After contact with stinging bristles of the caterpillar and with the pesticide Dimilin SC-48, of which diflubenzurone is the active agent, a 72-year-old man had to be resuscitated(More)
To evaluate the efficacy and safety of hirudin, a direct thrombin inhibitor, in patients with acute myocardial infarction, a dose-finding, angiography study was carried out. After a pilot phase in 10 patients treated with a bolus of 0.1 mg.kg-1 and a continuous infusion of 0.06 mg.kg-1.h-1 (dose group I), two doses of hirudin, bolus 0.2 mg.kg-1.h-1 (DG II),(More)
In this paper, a method is proposed for extraction of coupled networks from layout information for simulation of electrothermal device behavior. The networks represent a threedimensional (3-D) device structure with circuit elements. The electrical and thermal characteristics of this circuit representation are calculated with a circuit simulator. Spatial(More)