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Oxidation of NADH in the mitochondrial matrix of aerobic cells is catalysed by mitochondrial complex I. The regulation of this mitochondrial enzyme is not completely understood. An interesting characteristic of complex I from some organisms is the ability to adopt two distinct states: the so-called catalytically active (A) and the de-active, dormant state(More)
Understanding the human tactile system is the motivation for this research. The linear viscoelastic mechanical properties of the human fingerpad describe the stress-strain relationship within the fingerpad for any stimulus geometry and any time history of applied forces or displacements. The stress-strain relationships within the fingerpad tissue govern the(More)
An intriguing feature of mitochondrial complex I from several species is the so-called A/D transition, whereby the idle enzyme spontaneously converts from the active (A) form to the de-active (D) form. The A/D transition plays an important role in tissue response to the lack of oxygen and hypoxic deactivation of the enzyme is one of the key regulatory(More)
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