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The IEEE Nuclear and Plasma Sciences Society is an organization, within the framework of the IEEE, of members with principal professional interest in the field of plasma science. All members of the IEEE are eligible for membership in the Society and will receive this TRANSACTIONS upon payment of the annual Society membership fee of $25.00 plus an annual(More)
This report describes recommended techniques for radiopharmaceutical biodistribution data acquisition and analysis in human subjects to estimate radiation absorbed dose using the Medical Internal Radiation Dose (MIRD) schema. The document has been prepared in a format to address two audiences: individuals with a primary interest in designing clinical trials(More)
UNLABELLED Renal toxicity associated with small-molecule radionuclide therapy has been shown to be dose-limiting for many clinical studies. Strategies for maximizing dose to the target tissues while sparing normal critical organs based on absorbed dose and biologic response parameters are commonly used in external-beam therapy. However, radiopharmaceuticals(More)
A number of factors influence the accuracy of estimation of source volume with single-photon emission computed tomography (SPECT) imaging. This study investigated the role of a number of factors including system spatial resolution (which includes the influence of low-pass filters applied to suppress noise), source size and shape, and voxel size in(More)
The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of alpha-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with alpha-particle(More)
Severe hypertension causes global and regional changes in myocardial perfusion and substrate utilization. Regional perfusion and fatty acid utilization were evaluated by dual-tracer autoradiography in normotensive and hypertensive rats of the Dahl strain. The regional distributions of perfusion and fatty acid utilization were homogeneous in normotensive(More)
Semiquantitative methods such as the standardized uptake value ratio (SUVR) require normalization of the radiotracer activity to a reference tissue to monitor changes in the accumulation of amyloid-β (Aβ) plaques measured with positron emission tomography (PET). The objective of this study was to evaluate the effect of reference tissue normalization in a(More)
Recent Alzheimer's trials have recruited cognitively normal people at risk for Alzheimer's dementia. Due to the lack of clinical symptoms in normal population, conventional clinical outcome measures are not suitable for these early trials. While several groups are developing new composite cognitive tests that could serve as potential outcome measures by(More)
Introduction Research on developing 'imaging' methods for turbid media holds promise for applications in medicine and biology. Mammography in particular can benefit from an alternate diagnostic tool that does not involve either ionizing radiation or expensive measurement apparatus — particularly a method that holds promise of being able to differentiate(More)