A. Benjamin Spaeth

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0 Introduction As noted by Brown (1999), there is general agreement in the literature on Russian " genitive of negation " (GenNeg) that GenNeg occurs only when the NP in question is within the scope of sentential negation (NEG). The apparent optionality of GenNeg within the scope of negation is a point of difficulty, with authors divided about whether the(More)
Ammonium ions are ubiquitous in chemistry and molecular biology. Considerable efforts have been undertaken to develop synthetic receptors for their selective molecular recognition. The type of host compounds for organic ammonium ion binding span a wide range from crown ethers to calixarenes to metal complexes. Typical intermolecular interactions are(More)
Photodynamic inactivation of bacteria (PIB) by efficient singlet oxygen photosensitizers might be a beneficial alternative to antibiotics in the struggle against multiresistant bacteria. Phenothiazinium dyes belong to the most prominent classes of such sensitizers due to their intense absorption in the red-light region (λ(abs, max) ca. 600-680 nm, ε >(More)
Due to increasing resistance of pathogens toward standard antimicrobial procedures, alternative approaches that are capable of inactivating pathogens are necessary in support of regular modalities. In this instance, the photodynamic inactivation of bacteria (PIB) may be a promising alternative. For clinical application of PIB it is essential to ensure(More)
Highly resistant endospores may cause severe problems in medicine as well as in the food and packaging industries. We found that bacterial endospores can be inactivated quickly with reactive oxygen species (ROS) that were generated by a new generation of flavin photosensitizers. Flavins like the natural compound vitamin B2 are already known to produce ROS(More)
Photodynamic inactivation of bacteria (PIB) proves to be an additional method to kill pathogenic bacteria. PIB requires photosensitizer molecules that effectively generate reactive oxygen species like singlet oxygen when exposed to visible light. To allow a broad application in medicine, photosensitizers should be safe when applied in humans. Substances(More)
We have prepared a series of new and some literature-reported GABA-amides and determined their effect on the activation of GABAA-receptors expressed in CHO cells. Special attention was paid to the purification of the target compounds to remove even traces of GABA contaminations, which may arise from deprotection steps in the synthesis. GABA-amides were(More)
[a] Riboflavin (vitamin B 2) is essential for the health of humans and animals. Its structure is part of flavin adenine dinucleotide (FAD) and riboflavin-5'-phosphate (flavin mononucleotide, FMN), redox cofactors found among others in dehydrogenases, oxidases and photolyases. [1] A lack of vitamin B 2 can cause growth failure, seborrheic dermatitis or even(More)
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