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BACKGROUND The value of interferon-gamma release assays (IGRA) to diagnose active tuberculosis (TB) in children is not established, but these assays are being widely used for this purpose. The authors examined the sensitivity of commercially available IGRA to diagnose active TB in children in the UK compared with the tuberculin skin test (TST). METHODS(More)
A Bamford,1* A Turkova,2* H Lyall,3 C Foster,3 N Klein,4 D Bastiaans,5 D Burger,5 S Bernadi,6 K Butler,7 E Chiappini,8 P Clayden,9 M Della Negra,10 V Giacomet,11 C Giaquinto,12 D Gibb,13 L Galli,14 M Hainaut,15 M Koros,16 L Marques,17 E Nastouli,18 T Niehues,19 A Noguera-Julian,20 P Rojo,21 C Rudin,22 HJ Scherpbier,23 G Tudor-Williams24 and SB Welch25(More)
BACKGROUND Children with perinatally acquired HIV (paHIV) remain at an increased risk of pneumococcal infection despite highly active antiretroviral therapy (HAART). Beyond infancy, responses to pneumococcal conjugate vaccine (PCV) remain under-investigated. There are currently no published data on serological response to 13-valent PCV (PCV13) in the(More)
This review is an update focusing on the current status of paediatric HIV in the UK and Ireland. Successes in prevention of mother to child transmission are highlighted. The changing epidemiology of the UK cohort is summarised and the shift in emphasis of treatment guidelines beyond limiting short-term morbidity and mortality to ensuring optimal health(More)
Antiretroviral therapy (ART) only partially restores HIV-induced alterations in lymphocyte populations. We assessed B and T cell phenotypes in a cohort of children from a single centre in the United Kingdom with perinatally acquired HIV compared to healthy controls. The majority of HIV infected children (44 of 56) were on fully suppressive combination ART.(More)
The pathogenesis of Guillain-Barré syndrome (GBS) is considered to be, at least in part, mediated by autoantibodies directed against neuronal antigens. Antibodies to contactin-associated protein-like 2 (CASPR2), part of the voltage-gated potassium channel complex (VGKC-complex), are associated with neurological disease predominantly affecting the peripheral(More)
Non-attendance for barium enema investigation wastes resources, prolongs waiting times and delays diagnosis of colorectal carcinoma. In an inner-city hospital with a previous non-attendance rate of over 20% for barium enema we investigated the value of systematic personal contact with a nurse practitioner at the time of booking. We compared two groups of(More)
N-methyl-D-aspartate receptor antibodies (NMDAR-Abs) can contribute to neurological relapse after herpes simplex virus encephalitis (HSE). We describe a child with NMDAR-Ab encephalitis after HSE, which was recognized and treated early. We discuss the case in the context of existing reports, and we propose a modified immunotherapy strategy to minimize risk(More)
EN Menson,1 MJ Mellado,2 A Bamford,3 G Castelli,4 D Duiculescu,5 M Marczyńska,6 ML Navarro,7 HJ Scherpbier8 and PT Heath9 on behalf of the Paediatric European Network for Treatment of AIDS (PENTA) Vaccines Group, PENTA Steering Committee and Children’s HIV Association (CHIVA) 1Department of General Paediatrics, Evelina Children’s Hospital @St Thomas’(More)