A. B. Prokof’ev

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Rational drug use considers the medical, biological, and pharmaceutical factors that ensure high bioavailability and efficacy. On the other hand, the interaction of a drug with in vivo systems is of interest to take into account chronopharmacology, which studies drug action as a function of human biorhythms. According to chronopathology, various(More)
A rapid HPLC-MS/MS method for simultaneous determination of carbamazepine and carbamazepine- 10,11-epoxide in human blood serum was developed. The analytical range for carbamazepine was 50 – 20,000 ng/mL; for carbamazepine-10,11-epoxide, 5 – 2,000 ng/mL. This allowed the developed method to be used for therapeutic drug monitoring, bioequivalence studies,(More)
The present research was aimed at finding informative criteria for regulating the procedure to determine the interchangeability of systemic levofloxacin-based medicinal products (MP) registered in the RF. The chemical and pharmaceutical characteristics of excipients in 26 commercial levofloxacin products (film-coated tablets for internal use) were compared.(More)
Results from toxicological and pharmacological studies of the iron(II) coordination complex of the immunoactive dipeptide isoleucyltryptophan (timofer) were presented. It was established that timofer was practically nontoxic and exhibited high immunostimulatory activity when combined with viral and bacterial vaccines.
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