A. B. Linnik

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Carcinogenic risk of small doses of precursors of nitroso compounds, i.e. sodium nitrite (total dose in 0.2-2.0 g/mouse in drinking water) and morpholine (total dose is 0.23 g/mouse in bread) was studied in 520 CBA and 290 C57Bl mice during 96 weeks. It is shown that under these conditions the carcinogenic effect was more pronounced in CBA mice: there was a(More)
Tumors were induced in CBA mice or (C57BL×CBA)F1 hybrids by application of benzo-(a) pyrene (BP), 6-methyl-BP, 6-formyl-BP, or 7,12-dimethylbenz (a) anthracene (DMBA) to the dorsal skin. If 7,8-benzoflavone (BF) was mixed with the above compounds it reduced the carcinogenic action of the methyl-substituted hydrocarbons (DMBA and 6-methyl-BP) but did not(More)
CBA female mice received weekly subcutaneous injections of 1,2-dimethylhydrazine (1,2-DMH) in a dose of 8 mg/kg for 10 weeks (group 1). In groups 2,3 and 4 1,2-DMH plus estradiol dipropionate were administered for 10, 20 or 25 weeks, respectively. The incidence of uterine sarcoma in groups 1, 2, 3 and 4 was 3.3, 2.5, 65.4 and 73%, respectively. The mice(More)
This is the f i r s t study of a i rp lane engines as a source of carc inogenic pollution of the environment . R e m e m b e r i n g that soot f rom var ious types of a i rp lane engines can contain not only BP, but also o ther c a r cinogenic and cocarc inogenic subs tances , as well as subs tances inhibiting ca rc inogenes i s , it was decided to invest(More)
Carcinogenicity of the extract of "unorganized" emission of coke-oven batteries of the coke and by-product processes, 15 polycyclic hydrocarbons (PAH), solution of 4 carcinogenic PAH and benz(a)pyrene (BP) was studied in longterm experiments on (CBAXC57Bl/6)F1 hybrid mice. 1.5 ml of olive oil containing 1 mg of BP or the respective amount of PAH(More)