A B Begovich

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The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status

A. T. Lee, Wenjia Li, +7 authors P. K. Gregersen
Genes and Immunity
2005

We have recently described the association between rheumatoid arthritis and a coding single-nucleotide polymorphism in the intracellular protein tyrosine phosphatase, PTPN22. The disease-associated… (More)

Finnish case–control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis

M. F. Seldin, Russell Shigeta, +11 authors Jaakko O I Tuomilehto
Genes and Immunity
2005

Several studies have identified the PTPN22 allelic variant 1858 C/T that encodes the R620W amino-acid change as a putative susceptibility factor in autoimmune diseases. The current study was… (More)

Variants in the 5q31 cytokine gene cluster are associated with psoriasis

Ming Chang, Y. Li, +11 authors Steve Schrodi
Genes and Immunity
2008

A multitiered genetic association study of 25 215 single-nucleotide polymorphisms (SNPs) in three case–control sample sets (1446 patients and 1432 controls) identified three IL13-linked SNPs… (More)

Genetic variability and linkage disequilibrium within the HLA-DP region: analysis of 15 different populations.

A B Begovich, Priscilla V Moonsamy, +16 authors William Klitz
Tissue antigens
2001

In order to understand the forces governing the evolution of the genetic diversity in the HLA-DP molecule, polymerase chain reaction (PCR)-based methods were used to characterize genetic variation at… (More)

Detailed genetic characterization of the interleukin-23 receptor in psoriasis

Visitación García, Ming Chang, +11 authors Steve Schrodi
Genes and Immunity
2008

Using a multi-tiered, case–control association design, scanning 25 215 gene-centric SNPs, we previously identified two psoriasis susceptibility genes: IL12B and IL23R. These results have recently… (More)

Genes within the HLA class II region confer both predisposition and resistance to primary biliary cirrhosis.

A B Begovich, William Klitz, Priscilla V Moonsamy, Joseph M van de Water, Gary Peltz, M Eric Gershwin
Tissue antigens
1994

Nonradioactive sequence-specific oligonucleotide probes for the polymorphic HLA class II genes have been used to type samples from 51 Caucasian patients with the autoimmune liver disease, primary… (More)

Selection for T-cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis.

Jorge Oksenberg, Michael A. Panzara, +7 authors Christophe Bernard
Nature
1993

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system in which a restricted cellular immune response has been observed. In order to establish whether such T… (More)

HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course.

L. F. Barcellos, Jorge Oksenberg, +11 authors Simon Hauser
American journal of human genetics
2003

Models of disease susceptibility in multiple sclerosis (MS) often assume a dominant action for the HLA-DRB1*1501 allele and its associated haplotype (DRB1*1501-DQB1*0602 or DR2). A robust and… (More)

Localization of predisposition to Hodgkin disease in the HLA class II region.

William Klitz, Capt Shelley L Aldrich, N J Fildes, Sandra J. Horning, A B Begovich
American journal of human genetics
1994

Molecular typing of HLA class II loci has been performed on a sample of 196 patients with Hodgkin lymphoma. Division of patients into two histological categories--nodular sclerosing Hodgkin disease… (More)

The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population.

Joanna Wesoly, Xiaohui Hu, +7 authors T. W. J. Huizinga
Rheumatology
2007

OBJECTIVES A missense SNP, C1858T, in PTPN22 has been identified as a genetic risk factor for rheumatoid arthritis (RA). Subsequent work has suggested that other variants in this gene, in particular… (More)

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