A. Aspelund

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The central nervous system (CNS) is considered an organ devoid of lymphatic vasculature. Yet, part of the cerebrospinal fluid (CSF) drains into the cervical lymph nodes (LNs). The mechanism of CSF entry into the LNs has been unclear. Here we report the surprising finding of a lymphatic vessel network in the dura mater of the mouse brain. We show that dural(More)
A gradient free optimization-simulation method for processes modelled with the simulator Aspen HYSYS is developed. The tool is based on a Tabu Search (TS) and the Nelder-Mead Downhill Simplex (NMDS) method. The local optima that result from the TS are fine-tuned with NMDS to reduce the required number of simulations. The tool has been applied to find the(More)
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