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In this study, we analyse the process of spatial organisation of the cochlear root related to the morphological and topographical changes in the CN during the prenatal development of Wistar rats, placing special emphasis on aspects of the latero-medial distribution of the cochlear afferents. A total of 35 embryos from 8 Wistar rats was employed,(More)
Although the classical Golgi method is a powerful means for structural analysis of the brain, it is generally considered to be an unpredictable technique making anatomists wary of using it. Often, even when successful staining has occurred, deposits of silver chromate crystals on the surface of the tissue obscure examination. This paper describes a simple(More)
Physiological abnormalities resulting from death of dopaminergic neurons of the central nervous system in Parkinson's disease also extend to the retina, resulting in impaired visual functions. In both parkinsonian patients and animal models, low levels of dopamine and loss of dopaminergic cells in the retina have been reported. However, the morphology and(More)
PURPOSE Alpha-synuclein is a Parkinson's disease-linked protein of ubiquitous expression in the central nervous system. It has a proposed role in the modulation of neurotransmission and synaptic function. This study was aimed at analyzing expression of the alpha-synuclein gene in the normal retina, and characterizing its pattern of distribution in the(More)
The adult mammalian retina has for long been considered to lack a neurogenerative capacity. However, retinal stem/progenitor cells, which can originate retinal neurons in vitro, have been recently reported in the ciliary body of adult mammals. Here we explored the possibility of retinal neurogenesis occurring in vivo in adult monkeys and humans. We found(More)
Twenty-eight prenatal (14 to 20 days) Wistar albino rats were studied with Cajal-de Castro's silver reduced stain. The histological sections were oriented in a parasagittal oblique plane, parallel to the cochlear root, in order to observe the origin, course and destination of the cochlear fibres in as few consecutive sections as possible. In all the(More)
All retinal disorders, regardless of their aetiology, involve the activation of oxidative stress and apoptosis pathways. The administration of neuroprotective factors is crucial in all phases of the pathology, even when vision has been completely lost. The retina is one of the most susceptible tissues to reactive oxygen species damage. On the other hand,(More)
A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value of “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews,(More)
Golgi impregnations of one-month-old Wistar rats show 3 different neuronal types in the nucleus accumbens septi. These types could be clearly established on the basis of the size and shape of the soma and dendritic pattern; dendritic spines could not be used as a useful criterion for distinguishing among the 3 types. The type I neurons were the most widely(More)
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