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Achieving strategies to finely regulate with biological inputs the formation and functionality of DNA-based nanoarchitectures and nanomachines is essential toward a full realization of the potential of DNA nanotechnology. Here we demonstrate an unprecedented, rational approach to achieve control, through a simple change of the solution's pH, over an(More)
Here we demonstrate that we can rationally and finely control the functionality of different DNA-based nanodevices and nanoswitches using electronic inputs. To demonstrate the versatility of our approach we have used here three different model DNA-based nanoswitches triggered by heavy metals and specific DNA sequences and a copper-responsive DNAzyme. To(More)
This paper deals with the adaptation to wideband of the MBE coder which was initially developed for the telephone band. As the constraints of quality and bit rate for a wideband and a telephone band coder are different, and as the signal characteristics on these two bands are different too, we must reconsider the coder structure. Several improvements are(More)
Here we investigate a novel signal-on electrochemical DNA sensor based on the use of a clamp-like DNA probe that binds a complementary target sequence through two distinct and sequential events, which lead to the formation of a triplex DNA structure. We demonstrate that this target-binding mechanism can improve both the affinity and specificity of(More)
In this paper, we present an improved harmonic coder for the wideband. In an effort to improve spectrum modelling with harmonic representation, we include in the structure, a post error spectrum modelling that is essentially useful for noisy signals or mixed spectra of high pitch voices. The bit constrained error spectrum modelling procedure coupled with an(More)
By taking inspiration from nature, where self-organization of biomolecular species into complex systems is finely controlled through different stimuli, we propose here a rational approach by which the assembly and disassembly of DNA-based concatemers can be controlled through pH changes. To do so we used the hybridization chain reaction (HCR), a process(More)
Here we demonstrate that we can rationally and finely control the functionality of different DNA-based nanodevices and nanoswitches using electronic inputs. To demonstrate the versatility of our approach we have used here three different model DNA-based nanoswitches triggered by heavy metals and specific DNA sequences and a copper-responsive DNAzyme. To(More)