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- Luca Valenti, Mariagrazia Rumi, +9 authors Silvia Fargion
- Hepatology
- 2011
UNLABELLED
Steatosis has been reported to negatively influence the natural history of chronic hepatitis C (CHC), but controversy remains over its causal role due to the confounding effect of… (More)
- M G Rumi, A Aghemo, +6 authors Massimo Colombo
- Gastroenterology
- 2010
BACKGROUND & AIMS
Ribavirin (RBV) combined with either pegylated interferon (PegIFN) alpha2a or PegIFNalpha2b is the standard of care for chronic hepatitis C virus (HCV) infection. Due to the lack of… (More)
- A Aghemo, Raffaele De Francesco
- Hepatology
- 2013
Most direct-acting antivirals (DAAs) that are being developed as therapy against hepatitis C virus target the NS3/4A protease, the NS5A protein, and the NS5B polymerase. The latter enzyme offers… (More)
- P. D. J. Clark, A Aghemo, +9 authors Massimo Colombo
- Journal of viral hepatitis
- 2013
Anaemia frequently complicates peginterferon/ribavirin therapy for chronic hepatitis C infection. Better prediction of anaemia, ribavirin dose reduction or erythropoietin (EPO) need, may enhance… (More)
- Cristina Novembrino, A Aghemo, +8 authors Massimo Colombo
- Journal of viral hepatitis
- 2014
A cytoplasmic antigen associated to inosine-5'-monophosphatedehydrogenase 2 eliciting specific antibodies (antirods and rings, RR) has been identified in patients with chronic hepatitis C who were… (More)
- Roberta D'Ambrosio, A Aghemo, +5 authors Pierre Bedossa
- Hepatology
- 2012
UNLABELLED
Although annular fibrosis is the hallmark of cirrhosis, other microscopic changes that affect liver function such as sinusoid capillarization or loss of metabolic zonation are common. A… (More)
- Armando Tripodi, Massimo Primignani, +5 authors Pier Mannuccio Mannucci
- Hepatology
- 2010
UNLABELLED
Patients with cirrhosis possess an imbalance in procoagulant versus anticoagulant activity due to increased factor VIII and decreased protein C. This imbalance can be detected by… (More)
- Stella De nicola, A Aghemo, +9 authors Massimo Colombo
- Hepatology
- 2012
UNLABELLED
Single nucleotide polymorphisms (SNPs) near the interleukin 28B (IL28B) region are the strongest baseline predictors of a sustained virologic response (SVR) to peg-interferon (PegIFN) and… (More)
- Massimo Iavarone, Angelo Sangiovanni, +7 authors Massimo Colombo
- Hepatology
- 2010
UNLABELLED
Dynamic contrast imaging techniques are considered the standard of care for the radiological diagnosis of hepatocellular carcinoma (HCC) in cirrhosis. However, the accuracy of radiological… (More)
- Mirella Fraquelli, Mariangela Giunta, +10 authors Massimo Colombo
- Journal of viral hepatitis
- 2014
Liver transient elastography (L-TE) is a reliable, noninvasive predictor of disease severity in chronic liver disease of viral aetiology (CLD). Owing to the relationships among severity of CLD,… (More)