A. A. Vidotto

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BACKGROUND The development and progression of cancer depend on its genetic characteristics as well as on the interactions with its microenvironment. Understanding these interactions may contribute to diagnostic and prognostic evaluations and to the development of new cancer therapies. Aiming to investigate potential mechanisms by which the tumor(More)
Several body fluids have been evaluated as new sources for cancer biomarker discovery. In this context, salivary and serum proteomics seem promising diagnostic and predictive tools for head and neck diseases. In the present study, we performed a proteomic analysis of saliva and serum from patients presenting head and neck squamous cell carcinoma (HNSCC) and(More)
The prediction of tumor behavior for patients with oral carcinomas remains a challenge for clinicians. The presence of lymph node metastasis is the most important prognostic factor but it is limited in predicting local relapse or survival. This highlights the need for identifying biomarkers that may effectively contribute to prediction of recurrence and(More)
In the present study, we compared six different solubilization buffers and optimized two-dimensional electrophoresis (2-DE) conditions for human lymph node proteins. In addition, we developed a simple protocol for 2-D gel storage. Efficient solubilization was obtained with lysis buffers containing (a) 8 M urea, 4% CHAPS (3-[(3-cholamidopropyl)(More)
Proteomic approach has allowed large-scale studies of protein expression in different tissues and body fluids in discrete conditions and/or time points. Recent advances of methodologies in this field have opened new opportunities to obtain relevant information on normal and abnormal processes occurring in the human body. In the current report, the main(More)
Theoretical arguments and observations suggest that the atmospheres of Brown Dwarfs and planets are very dynamic on chemical and on physical time scales. The modelling of such substellar atmospheres has, hence, been much more demanding than initially anticipated. This Splinter 1 has combined new developments in atmosphere modelling, with novel observational(More)
Context. The principle definition of habitability for exoplanets is whether they can sustain liquid water on their surfaces, i.e. that they orbit within the habitable zone. However, the planet's magnetosphere should also be considered, since without it, an exoplanet's atmosphere may be eroded away by stellar winds. Aims. The aim of this paper is to(More)
Aims. Several studies suggest that the activity level of a planet-host star can be influenced by the presence of a close-by orbiting planet. Moreover, the interaction mechanisms that have been proposed, magnetic interaction and tidal interaction, exhibit a very different dependence on the orbital separation between the star and the planet. A detection of(More)
The magnetic fields, activity and dynamos of young solar-type stars can be empirically studied using time-series of spectropolarimetric observations and tomographic imaging techniques such as Doppler imaging and Zeeman Doppler imaging. In this paper we use these techniques to study the young Sun-like star EK Draconis (Sp-Type: G1.5V, HD 129333) using(More)