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The basic methods used in current practice for stable and transient expression of heterologous genes in plants are presented and compared. The key areas of research in the heterologous expression of genes in plants have been identified by analyzing literature and experimental data: modeling of metabolic pathways; creation of marker-free transgenic plants;(More)
The contribution of nucleotide composition of mRNA 5'-region to the efficiency of expression at transcriptional and translational levels was studied in transgenic tobacco plants (Nicotiana tabacum L., cultivar Petit Havana) using a thermostable lichenase reporter gene. Synthetic sequence that contains CG-rich motifs, typical for 5'-region of plant genes,(More)
It was suggested that the anthelmintic activity op benzimidazoles is based on their ability to interfere the assembly of microtubules – organellae present in both plant animal cells and playing an important role in chromosome transformations and other cell processes [3]. An important factor determining features of the biotransformation and pharmacokinetics(More)
A problem of current importance in modem pharmacology is the optimization of the pharmacological modulation of the immune response during infectious, oncological, and autoimmune pathology, transplantation, and immune disbalance accompanying chemotherapy. The activity of researchers is directed, in addition to more profound characterization of the known(More)
The relationship between structure and biological activity of azoles was previously theoretically studied for their antiviral [1], broncholytic [2], immunotropic [3, 4], and some other properties [5 8]. This analysis made it possible to formulate mathematical models capable of predicting these properties and to propose some potentially active and(More)
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