A. A. Shukakidze

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Morphological changes in neurons and the distributions of nerve and glial cells were studied, the glial index was calculated, and manganese (Mn) contents were determined in the caudate nucleus, the nucleus accumbens, the dorsal and ventral septal nuclei, and the frontoparietal areas of the cerebral cortex in the 40-day-old offspring of rats given different(More)
Single p.o. doses of manganese chloride (MnCl2·4H2O; 50 mg/kg) induced significant and reversible decreases in total activity in white rats, along with worsening of the acquisition of an avoidance reaction in response to unconditioned and conditioned stimuli, increases in the latent period of conditioned reflex activity, and a temporary worsening of the(More)
Manganese is an essential trace element for all living organisms. Though some neurological dysfunction take place during intoxication caused by excessive exposure of this metal. The goal of this research was to elucidate the emotional state, in particular anxiety and fear in three groups of young male rats. Two groups of 30 day old rat pups were given(More)
have demonstrated the important role of the neuroglia in the development of neurological derangements. In particular, it has been established that in a variety of pathological processes accompanied by nerve cell degeneration (Alzheimer’s disease, dementias of a variety of etiologies, parkinsonism, cerebral ischemia, etc.), activated microgliocytes and(More)
The effect of 30 days treatment with MnCl(2).4H2O (50 mg/kg in doze) on neuron ultrastructure and interneuronal contacts of cerebral cortex frontoparietal area was studied in rat. The material for the research was taken on 1st (group 1) and 4th (group 2) month of the experiment. Changes in neurons and cortex synapses were less significant than those in(More)
Ultrastructure of astrocytes, olygodendrocytes and microgliocytes of caudate nucleus, substantia nigra and frontoparietal area of the cortex were studied under the influence of the everyday peroral treatment with MnCl2.4H2O during 30 days. Experimental animals were divided into two groups. Animals from the first group received 20 mg/kg of MnCl2.4H2O while(More)
Single per oral administration of manganese chloride induced an obvious reversible diminishing of locomotor activity in white rats as well as deterioration of avoidance response to unconditioned and conditioned stimuli, prolongation of the conditioning latency, and a temporary deterioration of learning. Chronic manganese intoxication produced an(More)
The sensitivity of cerebral tissue to hyperthermia, its immediate effect, manifested by histological changes and the role of local blood flow, blood rheological properties, and the possible role of free radicals in development of mentioned changes have been studied. Through the cranial window local area of cerebral surface was irrigated by artificial CSF(More)
The morphological alterations in the neurons together with the distribution of the neural and glial cells were studied, the glial index was calculated, and manganese level was determined in n. caudatus, n. accumbens septalis, n. dorsalis and ventralis septalis, and in the fronto-parietal region of the brain cortex in the 40-day old offspring of the rats,(More)
show progressive extrapyramidal syndrome, mental disturbances and other symptoms which are very similar to those of Parkinson’s disease [5, 7, 10, 14, 18, 19]. At the initial stages of poisoning, the neurological defect is so severe that it hides pre-existing psychopathology, which subsequently becomes clearer. The progression of these disturbances leads to(More)