A. A. L. Fox

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Whereas vanadate increases isometric force of contraction in stimulated rat left atria (EC50 ∶ 36.6 μmol/l), it decreases force of contraction in guinea-pigs (EC50 ∶ 4.7 μmol/l). Action potential duration at 90 and 30% repolarisation is decreased in guinea-pig atria by 70 and 60%, but in rat atria by only 40 and 7% respectively. Whereas the time course of(More)
Extracellular matrix (stroma) regulation of mucosal T-cell function is incompletely understood. In this study, we uncovered a role for intestinal stromal products in the innate regulation of effector T cells. Stroma-conditioned media (S-CM) derived from the normal human intestinal stroma (transforming growth factor-β (TGF-β)hi/interleukin (IL)-6lo/IL-1βlo)(More)
The effect of the isoquinoline derivative 3-benzylamino-5,6-dihydro-8,9-dimethoxy-imidazo-5,1-a-isoquinoline-hydrochloride (BIIA) were studied in the cat in situ and guinea-pig isolated heart preparations: 1. Administration of BIIA (2 mg/kg i.v.) to anaesthetized cats results in a rapid rise in cardiac (dP/dt)max, decrease in heart rate and increase in(More)
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