A. A. Khusainov

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This paper presents some further evidence for our model of DNA translocation into Escherichia coli cells by bacteriophage T4 (see Tarahovsky, Y. S., Khusainov, A. A., Deev, A. A., Kim, Y. V. 1991. FEBS Lett. 289:18-22). When lowering the temperature, we succeeded in slowing down the infection process and in observing a few separate stages by electron(More)
By means of high-precision acoustic measurements and by methods of fluorescent and electron microscopy, investigations have been performed of thermoinduced conformational changes in T4 bacteriophage and its thermolabile mutants altered in baseplate proteins (gene products 7, 8, 10). A relationship was found between the conformational changes in T4(More)
The structural organization of the baseplate distal part of bacteriophage T4 has been studied. The investigations resulted in revealing the functional role of gene products '11' and '12' in the course of baseplate reorganization and DNA injection. A new model of 'arrangement' of gp12 in the intact particle is suggested. A functional interrelationship(More)
It has been shown that the complex functioning of the baseplate of the bacteriophage T4 is based on the high level hierarchy in the structure organization and on the interaction of protein components forming the hub and the "channels" of short and long fibers. The presence of structure proteins with stabilizing and destabilizing functions has been revealed.(More)
A model of the bacteriophage behavior at the reversible adsorption stage was investigated. The ratio of concentration of long fibres bound with receptors on bacterial surface to the total concentration of the fibres was taken to be efficiency range of reversible adsorption. To determine this value the expressions for concentrations of all the intermediate(More)