A A Hegarty

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Microdialysis was used to characterize the effects of two doses of ethanol, stress, and their interaction on the dopaminergic system. Saline-treated animals showed no changes in levels of dopamine (DA) or dihydroxyphenylacetic acid (DOPAC). Neither a 0.5- nor a 2-g/kg IP injection of ethanol had an effect on DA or DOPAC in resting animals. Immobilization(More)
The central cardiovascular effects of the circulating peptides angiotensin II (ANG II) and arginine vasopressin (AVP) may be mediated through the nucleus of the solitary tract (NTS). In this study, we used single-unit extracellular recording techniques to determine the effects of peripheral infusions of ANG II and AVP on NTS neurons. Barosensitive NTS(More)
The mesocortical dopamine system is thought to play an important role in the etiology of the stress response. Dopamine (DA) has been shown to accumulate in the rat frontal cortex in response to a wide variety of stressors. Diazepam, an anxiolytic benzodiazepine, can reverse the effects of stress on cortical DA. We investigated the effects of acute and(More)
Arginine vasopressin (AVP) may act as a neurotransmitter or neuromodulator in the solitary tract nucleus (NTS). To determine whether AVP influences the activity of NTS neurons receiving cardiovascular afferent input, we used single-unit extracellular recording combined with local microinjection to test the effects of AVP and V1-receptor antagonists (antAVP)(More)
The effects of electrical and chemical stimulation of the area postrema (AP) on mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA) were examined in urethan- and pentobarbital sodium-anesthetized rats and in unanesthetized decerebrate rats. The AP was electrically stimulated over a range of frequencies (10-100 Hz) and intensities (10-80(More)
Previous work has shown that arginine vasopressin (AVP) present in the nucleus tractus solitarius (NTS) contributes to the control of peripheral cardiovascular parameters such as arterial pressure, heart rate, and sympathetic activity. In this study, we attempted to elucidate the influence of AVP in the NTS on baroreflex control of mean arterial pressure(More)
Morquio disease (mucopolysaccharidosis type IV) is an autosomal recessive lysosomal storage disorder causing predominantly skeletal manifestations. It is caused by a deficiency of galactose-6-sulphatase. In classical Morquio disease there is extreme short stature with height being between 90 and 120 cm. We have identified 10 individuals in Northern Ireland(More)
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