A. A. Gamburyan

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Chromatographic study (TLC and GLC) of the reaction products with the example of the reaction of benzilic acid (V) with ethyl alcohol in the presence of sulfuric acid showed that in addition to the main product, the ethyl ester of benzilic acid (VI), there is also formed another product (VII) with a boiling point close to the boiling point of compound VI.(More)
Pharmacological investigations showed that benzylic acid ~-diethylaminoethyl ester hydrochloride, amizyl, has cholinolytic and gangliolytic properties [8]. To study the changes in the cholinolytic action of amizyl, when two bromine atoms are introduced into its acid part at the 4,4'-positions of the phenyl groups, and also on altering the aminoalkanol(More)
The rearrangement products (Table i), investigated by thin-layer chromatography, GLC, IR, NMR, and by conventional synthesis, confirm the rearrangement mechanism proposed by us earlier [i]. The following side-reaction products were determined: HOCnH2nNR2 (V), p-XC~(C~Hs)CHCI (VI), [p-XC~H~(C~H,)-CHOH]2 (VII), [p-XC6H4(CsHs)CH]20 (VIII), (R2NCnH2n)20 (IX),(More)
The present work is a continuation of earlier studies [i, 2], and was carried out to show the influence of a hydroxyl group in the amino-alcohol chain on the pharmaceutical activity of dialkylaminopropyl esters and amides of substituted acetic acids, The syntheses of hydrochlorides of the 2-hydroxy-3-diethylaminopropyl esters of diphenylacetic and(More)
Of the compounds I obtained, some were those described in the literature: this made 9 it possible to make a comparative evaluation of the investigated properties. Equimolar amounts of benzhydryl chlorides and amino alcohols were mixed, and the salts were obtained as solid vitreous products. The purification of the salts was accomplished by dissolving them(More)
It was establ ished previously that the introduction of an alkoxyl group into the p-posi t ion of one of the benzene rings of diphenhydramine led to an increase in the breadth of the therapeut ic action with re tent ion or enhancement of the ant ihis tamine activity [3, 4]. In addition the possibi l i ty has been repor ted of strengthening the nicotinolytic(More)
On t h e b a s i s o f t h i s a n d a l s o o f t h e e x p e r i m e n t a l d a t a o b t a i n e d w e c a m e t o t h e c o n c l u s i o n that the main route (A) of the reaction, after the thermal heterolytic fission of the ammonium salt, included the interaction of the benzhydryl carbonium ion with the nucleophile (oxygen) by the elimination of a(More)
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