The role and interpretation of pilot studies in clinical research.
- A. LeonL. DavisH. Kraemer
- 1 May 2011
Medicine
The roles and limitations of pilot studies are described here using a clinical trial as an example to evaluate the feasibility of recruitment, randomization, retention, assessment procedures, new methods, and implementation of the novel intervention.
Prevalence of post-traumatic stress disorder in the United States: a systematic literature review
PTSD prevalence estimates varied widely, partly due to different study designs, populations, and methodologies, and recent nationally representative estimates were lacking; efforts to increase PTSD screening and improve disease awareness may allow a better detection and management of PTSD.
Prevalence of posttraumatic stress disorder in Veterans Affairs primary care clinics.
- K. MagruderB. Frueh G. Arana
- 1 May 2005
Psychology, Medicine
The prevalence of PTSD using Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition diagnostic criteria in Veterans Affairs (VA) primary care settings and associated sociodemographic characteristics and comorbidities was estimated to be 11.5%.
Major depression and comorbid substance use disorders
- L. DavisA. UezatoJason M. NewellElizabeth Frazier
- 1 January 2008
Medicine, Psychology
Emerging results of recent studies comparing the outcome of major depressive disorder patients with comorbid major depressive Disorder and substance use disorders suggest that there are fewer differential effects based onComorbidity than previously anticipated by older assumptions from smaller, less methodologically rigorous studies.
The Economic Burden of Posttraumatic Stress Disorder in the United States From a Societal Perspective.
The economic burden of PTSD goes beyond direct health care costs and has been found to rival costs for other costly mental health conditions and may need to be reduced to reduce the large clinical and economic burden.
Tranylcypromine versus venlafaxine plus mirtazapine following three failed antidepressant medication trials for depression: a STAR*D report.
- P. McGrathD. M. A. J. Rush
- 1 September 2006
Medicine
The lower side effect burden, lack of dietary restrictions, and ease of use of venlafaxine and mirtazapine suggest that this combination may be preferred over tranylcypromine for patients with highly treatment-resistant depression who have not benefited adequately from several prior treatments.
A randomized controlled trial of supported employment among veterans with posttraumatic stress disorder.
Veterans with PTSD who received individual placement and support supported employment were 2.7 times more likely to gain competitive employment than those who received VRP.
It Is Time to Address the Crisis in the Pharmacotherapy of Posttraumatic Stress Disorder: A Consensus Statement of the PTSD Psychopharmacology Working Group.
- J. KrystalL. Davis Grant D. Huang
- 14 March 2017
Medicine, Psychology
There is an urgent need to address a critical lack of advancement in the psychopharmacologic treatment of posttraumatic stress disorder (PTSD), and research and development of new medications for the treatment of PTSD has stalled and there is a void in new drug development.
Predictors of attrition during initial (citalopram) treatment for depression: a STAR*D report.
- M. D. WardenM. Trivedi A. Rush
- 1 August 2007
Medicine, Psychology
In clinical trials and clinical practice, several time points in treatment may provide opportunities to engage and encourage populations at higher risk for attrition and populations with high-risk presentation of illness.
Comparison of Prolonged Exposure vs Cognitive Processing Therapy for Treatment of Posttraumatic Stress Disorder Among US Veterans A Randomized Clinical Trial
- P. SchnurrKathleen M Chard M. Shih
- 4 January 2022
Psychology, Medicine
Although PE was statistically more effective than CPT, the difference was not clinically significant, and improvements in PTSD were meaningful in both treatment groups, these findings highlight the importance of shared decision-making to help patients understand the evidence and select their preferred treatment.
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