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Biological activities of a recombinant adenovirus p53 (SCH 58500) administered by hepatic arterial infusion in a Phase 1 colorectal cancer trial
Biological responses to a replication-defective adenovirus encoding the p53 transgene when administered by hepatic arterial infusion to patients with primarily colorectal cancer metastatic to the liver were evaluated.
Assessment of p53 gene transfer and biological activities in a clinical study of adenovirus-p53 gene therapy for recurrent ovarian cancer
Gene transfer and its expression were observed in cells obtained from peritoneal aspirates, indicating that successful gene transfer can be achieved by multiple cycle intraperitoneal administration of recombinant adenovirus.
Interferon α2b gene delivery using adenoviral vector causes inhibition of tumor growth in xenograft models from a variety of cancers
- C. M. Ahmed, Duane E. Johnson, +11 authors B. Sugarman
- Medicine, BiologyCancer Gene Therapy
- 1 October 2001
IACB was tested in a metastatic model in beige/SCID mice generated with H69 (small cell lung carcinoma) cells and was found to prolong survival in tumor-bearing animals, suggesting that interferon gene delivery can be effective in suppressing tumor growth in a wide variety of cells.
Adenoviral Delivery of Human and Viral IL-10 in Murine Sepsis1
It is concluded that adenoviral vectors can be administered prophylactically in acute inflammatory syndromes, and expression of the anti-inflammatory protein IL-10 can be used to suppress the underlying inflammatory process.
Adenovirus-Mediated Gene Therapy Using Human p21WAF-1/Cip-1to Prevent Wound Healing in a Rabbit Model of Glaucoma Filtration Surgery
Mitomycin and rAd.p21 were effective in preventing fibroproliferation and wound healing in a rabbit model of glaucoma surgery, without the complications associated with mitomycin.
Specific depletion of human anti-adenovirus antibodies facilitates transduction in an in vivo model for systemic gene therapy.
- A. Rahman, V. Tsai, +7 authors P. Shabram
- Biology, MedicineMolecular therapy : the journal of the American…
- 1 May 2001
Depletion of both murine and human anti-adenoviral antibodies can restore transduction in vivo during systemic rAd gene therapy in hosts previously exposed to adenovirus, and this model is developed to assess the effect of human and mouse anti- Adenovirus antibodies on systemic administration of a rAd vector expressing beta-galactosidase.
Adenovirus-mediated gene therapy using human p21WAF-1/Cip-1 to prevent wound healing in a rabbit model of glaucoma filtration surgery.
Mitomycin and r adenovirus-mediated p21(WAF-1/Cip-1) (p21) gene therapy can prevent fibroproliferation and wound healing in a rabbit model of glaucoma filtration surgery, without the complications associated with mitomycin.
Adenovirus-Mediated Gene Therapy Using Human p 21 WAF-1 / Cip-1 to Prevent Wound Healing in a Rabbit Model of Glaucoma Filtration Surgery
Methods: In vitro studies were performed using rabbit Tenon fibroblasts harvested from fresh tissue. In vivo studies were conducted in New Zealand white rabbits. A fullthickness sclerotomy was…