Skip to search formSkip to main contentSkip to account menu

Erythropoietin receptor in B cells plays a role in bone remodeling in mice

Erythropoietin (EPO) is a key regulator of erythropoiesis. However, EPO receptors (EPO-Rs) are also expressed on non-erythroid cell types, including myeloid and bone cells. Immune cells also…
PDF (opens in a new tab)

Extrahepatic cholangiocyte obstruction is mediated by decreased glutathione, Wnt and Notch signaling pathways in a toxic model of biliary atresia

A novel pathway of cholangiocyte injury in a model of biliary atresia is presented, which is relevant to human BA and may suggest potential future therapeutics.
Springer Nature (opens in a new tab)

Erythropoietin enhances Kupffer cell number and activity in the challenged liver

A new role for EPO is revealed in stimulating KC proliferation and phagocytosis, and in recruiting Ly6Chi monocytes in response to liver injury in a model of acute acetaminophen-induced liver injury.
Springer Nature (opens in a new tab)

Recombinant Erythropoietin and Darbepoetin Alpha Exert a Similar Dose-Dependent Osteopenic Effect Which May Advocate for "Start Low, Go Slow" Dosing Strategy in Clinical Practice

Applying clinically comparable dosing regimen, both recombinant EPO and DA exert a similar, dose-dependent bone loss, not directly proportional to the erythroid response, however, DA, in contrast to EPO, spares the preosteoblast and bone marrow B cell populations.
Publisher (opens in a new tab)

Transdifferentiation of Bone Marrow Pro-B Cells into Bone-Resorbing Osteoclasts- an Unexpected Role for Erythropoietin

A new physio-pathological role for BM B cell precursors in bone metabolism, via their capacity to differentiate into functional osteoclasts, and a possible role for EPO in this process is suggested.
Publisher (opens in a new tab)

Erythropoietin Mediated Increase in Monocyte-Derived Liver Macrophages; A Role for Kupffer Cells?

The present study points to a new as hitherto unexplored action of EPO on two separate liver macrophage populations (Kupffer cells and MFs) which play crucial and distinct roles in liver homeostasis and immunity as well as in liver pathologies.
Publisher (opens in a new tab)

Liver Macrophages (Kupffer cells) As Novel Targets of Erythropoietin

Using transgenic mice, overexpressing human EPO (tg6 mice), it is found that they have a 2 fold increased level of F4/80 positive liver macrophages, compared to wt mice, suggesting that EPO may have pleiotropic activities.
Publisher (opens in a new tab)
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)