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Contractile forces direct the chiral swirling of minimal cell collectives

The findings establish that the level of mechanical energy developed by pairs of confined endothelial cells regulates the strength and direction of their rotation, and identify the more contractile cell of the doublet as the cell driving the direction and speed of rotation of the pair.
PubMed (opens in a new tab)

Competing forces of polarization and confinement generate cellular chirality in a minimal model

A coherent theory is presented, based on dynamical system analysis, that captures chirality emergence in a singlet and doublet cell system and demonstrates that cytoskeletal contractility modulates the chirality bias.
arXiv (opens in a new tab)

Role of contractility in the chiral swirling of endothelial cells

The results demonstrate that an optimal amount of forces and focal adhesion strength is required to maintain the persistent rotation of the cell doublets and show that any deviation from this optimum impairs not only the rotation of the doublets but also its bias, resulting in, either its enhancement or complete reversion.
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