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Serine peptidases: Classification, structure and function
  • M. Page, E. Cera
  • Biology
    Cellular and Molecular Life Sciences
  • 9 February 2008
This work describes the known diversity of serine peptidases with respect to structure and function and places particular emphasis on the S1 peptidase family, the trypsins, which underwent the most predominant genetic expansion yielding the enzymes responsible for vital processes in man.
Role of Na+ and K+ in enzyme function.
From this analysis, M+ complexation has the potential to be an efficient regulator of enzyme catalysis and stability and offers novel strategies for protein engineering to improve enzyme function.
Proteases as therapeutics.
Proteases have a bright future as a distinct therapeutic class with diverse clinical applications and the recognition that proteases are an established class of safe and efficacious drugs will stimulate investigation of additional therapeutic applications for these enzymes.
E/Z-rubrolide O, an anti-inflammatory halogenated furanone from the New Zealand ascidian Synoicum n. sp.
Bioassay-directed fractionation of extracts of a Synoicum n. sp. ascidian from New Zealand led to the isolation of the principal anti-inflammatory component, which was identified by spectroscopic
Thrombin allostery.
This review summarizes the current understanding of the molecular basis of thrombin allostery with special emphasis on the kinetic aspects of Na(+) activation.
Anti-inflammatory thiazine alkaloids isolated from the New Zealand ascidian Aplidium sp.: inhibitors of the neutrophil respiratory burst in a model of gouty arthritis.
Two new tricyclic thiazine-containing quinolinequinone alkaloids were isolated from the New Zealand ascidian Aplidium species and inhibited the in vitro production of superoxide by PMA-stimulated human neutrophils in a dose-dependent manner.
Evolution of Peptidase Diversity*
Application of the MEROPS classification to a comprehensive set of genomes yields a simple pattern of peptidase distribution and provides insight into the organization of proteolysis in all forms of life.
Spatial and temporal variability of the bacterial community in different chemotypes of the New Zealand marine sponge Mycale hentscheli.
The spatial and temporal complexity in the distribution of bacterial communities associated with different chemotypes of the marine sponge M. hentscheli is highlighted, with sequences having similarity to sponge-associated bacteria reported from global locations.