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  • 吴国生, 章雁, +4 authors 肖志梅
  • Chemistry
  • 14 May 2014
  • 本发明涉及磷酸二酯酶5抑制剂他达拉非的制备方法,以D‑色氨酸甲酯盐酸盐为起始原料,经与胡椒醛环合、N‑酰化、胺解‑环合等反应得到他达拉非粗品,他达拉非粗品重结晶得到他达拉非成品。 本发明提供的制备他达拉非方法,反应条件温和,反应时间较短,收率高,产品稳定性好,便于工业化生产。