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本文将人工合成的编码GPRP四伏的寡核甙酸序列连接 scu-PAcDNA的5’端,并将它重组克隆到表达载体pKKK233-2中,在大肠杆菌中得到5%表达量。表达产物经亲和层析得到纯化,并测得其Km为40μmol/L。体外纤咬继LUK的2-3倍,对纤维蛋白的亲和性比LUK提高了6倍,并且对纤维蛋白原的亲和力很低。