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STUDIES ON THE RELATIONSHIP BETWEEN THE MO REACTIVITY INDICES AND REVERSIBLE ANTICHOLINESTERASE ACTIVITY OF CUIXINGNING
Reversible anticholinesterase (anti-ChE)agents can inhibit the function of acetylcholinesterase (AChE)temporarily and have been used in the treatment of glaucoma and myasthenia gravis, and recentlyExpand
异黄酮衍生物的合成I.7-甲氧基-3′-N,N-二烷胺甲基-4′-烃基异黄酮的合成
合成了异黄酮衍生物1458,1441和1461。它们的合成是由间-苯二酚与对-硝基苯乙腈经Hoesh反应,制得(Ⅱ)。化合物(Ⅱ)与原甲酸乙酯环化成7-羟基-4′-硝基异黄酮(Ⅳ)。化合物(Ⅳ)中的硝基还原成氨基,再经重氮化,水解生成化合物(Ⅷ)。化合物(Ⅷ)经Mannich反应,合成了1458、1441、1461。合成的异黄酮衍生物对小鼠所做耐氧试验表明,1461具有明显的小鼠耐缺氧作用。
STUDIES ON THE CONFORMATIONS OF SUBEROGORGIN AND ITS METHYL ESTER BY MNDO METHOD
The novel reversible anticholinesterase (anti-ChE) agent suberogorgin (S) has potent anti-ChE activity and lower toxicity and is possible to become the new drug for the treatment of senile dementiaExpand