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目的探讨 21-氨基类固醇 U- 74389G对脑外伤后脑保护作用。方法用记忆功能测定箱,对中度脑损伤大鼠不同时期的记忆功能进行测试评分,并进行脑组织病理检查。结果伤前及伤后早期给药能显著提高脑损伤大鼠的记忆功能水平,减轻神经病理损害。结论 U- 74389G对大鼠脑外伤后记忆功能有保护作用。