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Methods and compositions for increasing the arylsulfatase a activity in Cns
The present invention provides methods and compositions for treating a subject afflicted with arylsulfatase A deficiency in CNS. The method comprises the systemic administration of bifunctionalExpand
The methods and compositions for increasing the alpha-L-iduronidase activity of the central nervous system
TLDR
The method comprises the systemic administration of bifunctional fusion antibody comprising an antibody against human insulin receptor and alpha-L-iduronidase and Therapeutically effective systemic dose, based on the specific CNS uptake characteristics of human insulin receptors antibody . Expand
The methods and compositions for increasing the iduronic acid 2-sulfatase activity in Cns
This application provides methods and compositions for treating a subject suffering from iduronic acid 2-sulfatase deficiency in CNS. The method comprises the systemic administration of bifunctionalExpand
Methods and compositions for increasing the enzyme activity in Cns
Herein provide methods and compositions for treating a subject suffering from an enzyme deficiency in the central nervous system (CNS). Bifunctional fusion antibodies herein, antibodies to endogenousExpand