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Methods and compositions for increasing the arylsulfatase a activity in Cns
The present invention provides methods and compositions for treating a subject afflicted with arylsulfatase A deficiency in CNS. The method comprises the systemic administration of bifunctionalExpand
Blood-brain barrier transport for the fusion protein
The present invention increases the transport of drugs across the blood brain barrier, once activity that passed through the barrier compositions to allow being substantially completely maintained,Expand
The methods and compositions for increasing the alpha-L-iduronidase activity of the central nervous system
The present invention provides methods and compositions for treating a subject afflicted with alpha-L-iduronidase deficiency in CNS. The method comprises the systemic administration of bifunctionalExpand
Material for the blood-brain barrier delivery
In the present invention, some embodiments, while facilitating the transport of substances across the blood-brain barrier in both directions substantially compositions retain intact its activity atExpand
The methods and compositions for increasing the iduronic acid 2-sulfatase activity in Cns
This application provides methods and compositions for treating a subject suffering from iduronic acid 2-sulfatase deficiency in CNS. The method comprises the systemic administration of bifunctionalExpand
Methods and compositions for increasing the enzyme activity in Cns
Herein provide methods and compositions for treating a subject suffering from an enzyme deficiency in the central nervous system (CNS). Bifunctional fusion antibodies herein, antibodies to endogenousExpand