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Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans.
Choline acetyltransferase (ChAT; EC ) catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Mutations in genes encoding ChAT affectingExpand
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The Plasma Membrane Calcium Pump Displays Memory of Past Calcium Spikes
To understand how the plasma membrane Ca2+ pump (PMCA) behaves under changing Ca2+ concentrations, it is necessary to obtain information about the Ca2+ dependence of the rate constants for calmodulinExpand
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Analysis of growth of multicellular tumour spheroids by mathematical models
Abstract. We wished to determine the applicability of previously proposed deterministic mathematical models to description of growth of multicellular tumour spheroids. The models were placed intoExpand
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Modeling of cancer virotherapy with recombinant measles viruses.
The Edmonston vaccine strain of measles virus has potent and selective activity against a wide range of tumors. Tumor cells infected by this virus or genetically modified strains express viralExpand
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Combining Gompertzian growth and cell population dynamics.
A two-compartment model of cancer cells population dynamics proposed by Gyllenberg and Webb includes transition rates between proliferating and quiescent cells as non-specified functions of the totalExpand
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The Metal-binding Properties of DREAM
DREAM, an EF-hand protein, associates with and modulates the activity of presenilins and Kv4 potassium channels in neural and cardiac tissues and represses prodynorphin andc-fos gene expression byExpand
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The Rate of Activation by Calmodulin of Isoform 4 of the Plasma Membrane Ca2+ Pump Is Slow and Is Changed by Alternative Splicing*
A reconstitution system allowed us to measure the ATPase activity of specific isoforms of the plasma membrane Ca2+ pump continuously, and to measure the effects of adding or removing calmodulin. TheExpand
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Binding, internalization, and intracellular processing of proteins interacting with recycling receptors. A kinetic analysis.
We measured time-dependent concentration changes of human interferon-alpha 2a (IFN) and human tumor necrosis factor-alpha (TNF) bound at the plasma membrane and internalized by human lung alveolarExpand
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Functional consequences and structural interpretation of mutations of human choline acetyltransferase
Choline acetyltransferase (ChAT; EC 2.3.1.6) catalyzes synthesis of acetylcholine from acetyl‐CoA (AcCoA) and choline in cholinergic neurons. Mutations in CHAT cause potentially lethal congenitalExpand
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Gompertzian growth as a self-similar and allometric process.
  • Ž. Bajzer
  • Medicine, Biology
  • Growth, development, and aging : GDA
  • 1999
The Gompertz law of growth has puzzled scientists for decades: while it successfully described growth kinetics of various biological systems (e.g., tumor growth), its foundation has remained unclear.Expand
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