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Serum profiles of free and conjugated neuroactive pregnanolone isomers in nonpregnant women of fertile age.
The results indicate that a substantial proportion of the progesterone is metabolized in the sequence progester one-->5beta-dihydroprogesterone-->P3alpha5beta-->conjugated P3alpha 5beta, which suggests a gonadal source of PI in the luteal phase. Expand
Dehydroepiandrosterone: A neuroactive steroid
A short overview of the possible actions of dehydroepiandrosterone and its sulfate in the brain is presented, calling attention to various mechanisms of their action as neurosteroids and to prospects for the knowledge of their role in brain disorders. Expand
Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects.
It is concluded that DHEA measurements cannot be a substitute for DHEAS and vice versa and indicates the possible variable secretion and dynamics of their (inter)conversion. Expand
Neuroactive steroids in periphery and cerebrospinal fluid
Brain synthesis may provide minimal level of neurosteroids, which are indispensable for the CNS functions, but substantial part of the steroid metabolites may be also synthesized in the CNS from the steroid precursors or directly transported through BBB from the periphery. Expand
Peripheral neuroactive steroids may be as good as the steroids in the cerebrospinal fluid for the diagnostics of CNS disturbances
The data show that a part of the steroids may be synthesized de novo in the CNS from the steroid precursors or directly transported from the periphery, and substantial part ofthe steroid metabolites may be synthesisized in thecephalus. Expand
Homocysteine and steroids levels in metformin treated women with polycystic ovary syndrome.
Treatment with metformin in women with PCOS can lead to the increase in homocysteine levels--a risk factor for atherosclerosis. Expand
What may be the markers of the male equivalent of polycystic ovary syndrome?
Investigation of a group of 30 men with premature alopecia, in which premature hair loss started before 30 years of age, found a subgroup with hormonal changes resembling those of women with PCOS showed a significantly higher insulin resistance than the group without these changes. Expand
Do DHEA/DHEAS play a protective role in coronary heart disease?
It is concluded that there is no evidence of a protective role of DHEA and DHEAS in women, and men with low plasma DHEAs levels can be considered as beings at risk of developing a fatal cardiovascular event. Expand
  • Ľ. Stárka
  • Medicine
  • The Journal of Steroid Biochemistry and Molecular…
  • 31 October 2003
It can be presumed that epitestosterone as a natural hormone can contribute to the regulation of such androgen dependent events as, e.g. the control of prostate growth or body hair distribution. Expand
Neurosteroid 7-hydroxylation products in the brain.
Activation of 7 alpha-hydroxylation by increased close contacts of astrocytes and after glucocorticoid treatment suggested that the regulated production of 7alpha-hydroxysteroids was a key event for the neuroprotection conferred by neurosteroids. Expand